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	Welcome to MOLTOOLS Advanced Molecular Tools for Array-based Analyses of Genomes New molecular tools will give us the opportunity to identify all molecules encoded in our genomes, even at the single-molecule level, and to do this in individual patient samples. The EU FP6 project MolTools aims to promote the development and implementations of such tools by bringing together leading European groups in the area of molecular technology development. We welcome you to come see us at this website, to benefit from and to influence the development of molecular tools for the postgenomic era. Ulf Landegren Coordinator of MolTools Please click here to see the list of people involved.

	Public MolTools symposium, June 5, DKFZ, Heidelberg
	In connection to the final MolTools meeting in Heidelberg there will be a public symposium on June 5, 2007 at the DKFZ. Organisers are Jörg D Hoheisel, Annemarie Poustka and Peter Lichter. More information about the meeting is found

	2nd Paris Workshop on Molecular and Statistical and Genomic Epidemiology
	MolTools partner CNG (Ivo Gut) and colleagues are organizing a genomic epidemiology workshop. A number of MolTools consortium partners are presenting at this workshop which is a follow up to the 2005 Paris workshop. Workshop Title: '2nd Paris Workshop on Molecular and Statistical and

	MolMeth - The Molecular Methods Database
	The Molecular Methods Database (MolMeth) is currently being developed to provide the research community with a reliable source of methods and protocols used in molecular biology and molecular medicine. A link to the website will shortly open HERE. MolMeth is a structured database

	MolTools Folder
	Please click here to download Moltools - pdf.

	2005 Lasker Award to Ed Southern
	The prestigious Albert Lasker Award for Clinical Medical Research for year 2005 is shared between MolTools partner Sir Edwin Southern and Alec Jeffreys. Ed Southern won the award for his invention Southern Blot Hybridization, a techniques that revolutionized genetics. Suddenly scientists could

FEATURES

Direct observation of individual endogenous protein complexes in situ by proximity ligation

A new paper in Nature Methods (Nat Methods. 2006 Oct 29) by Söderberg et al from Uppsala University.
myc-max interaction in situ

Abstract
Cellular processes can only be understood as the dynamic interplay of molecules.

Single-nucleotide polymorphisms: analysis by mass spectrometry

A collaborative project in WP2 between Sascha Sauer at the Max Planck Institute, Berlin and Ivo Gut at CNG, Paris published in Nature Protocols 1:4:2006

Abstract:
Matrix-assisted laser desorption-ionization (MALDI) mass spectrometry has evolved as a powerful method for

Digital quantification using amplified single molecule detection

A new paper in Nature Methods (2006:3:725-727) from MolTools partner Mats Nilsson and his research group in Uppsala. The plastic microstructures used are designed by MolTools partner Åmic.

Abstract:
We describe a scheme for biomolecule enumeration by
converting

Microarray technology: beyond transcript profiling and genotype analysis

A review by MolTools partner Jörg Hoheisel published in Nature Review Genetics 2006, Vol 7, 200 - 209.
Abstract: Understanding complex functional mechanisms requires the global and parallel analysis of different cellular processes. DNA microarrays have become synonymous with this kind of study

Miniaturization in functional genomics and proteomics

Nature Reviews Genetics 6, 465-476 (2005); written by MolTools partners Sascha Sauer, Bodo M. H. Lange, Johan Gobom, Lajos Nyarsik, Harald Seitz & Hans Lehrach at MPG, Berlin.

Abstract
Proteins are the key components of the cellular machinery responsible for processing changes

In situ genotyping individual DNA molecules by target-primed rolling circle amplification of padlock probes

In the course of Work Package 5, Mats Nilsson´s group at Uppsala University, together with Jörn Koch at Aarhus University, have used a combination of padlock probes and rolling circle amplification to demonstrate in

Genotyping single nucleotide polymorphisms by MALDI mass spectrometry in clinical applications

A review by MolTools partners Jörg Tost and Ivo Gut, published in J Clin Biochem April 2005

Abstract
Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has become one of the most powerful and widely applied technologies for SNP scoring

Peptide nucleic acids on microarrays and other biosensors

A review by Ole Brandt and Jörg Hoheisel

Abstract
The analysis of biomolecules using microarrays and other biosensors has a significant role in molecular biotechnology, and will become even more important in the future as a versatile tool for research and diagnostics. For

Advanced sequencing technologies: methods and goals

Review published in Nature Reviews Genetics May 2004. Contributed by George Church and colleagues, Harvard Medical School. Article pdf

	New EMBO members
	MolTools partners Ulf Landegren, Uppsala University, and Olli Kallioniemi, VTT, have been selected to be a members of the organization EMBO (European Molecular Biology Organization), which supports outstanding research in molecular life science in Europe. EMBO Membership is a life-long honour and

	4th MolTools symposium
	The next MolTools meeting will will take place at the DKFZ in Heidelberg on June 5-6 2006. On June 5 consortium partners will give a public symposium. Program details and more information about the symposium will be posted here shortly.

	MIACA - Minimum Information About a Cellular Assay
	The MIACA initiative on Minimum Information About a Cellular Assay develops guidelines for the description of experiments and data from cell based assays. Advances in genomics and functional genomics have enabled large scale analysis of gene and protein function by means of high throughput cell

	MolTools first year
	A short summary of the first year of MolTools is found here.

	EU genomics news letter
	The MolTools project is presented in the latest EU genomics news letter Previous issues this year: Number 1:

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